Reaktion #10694

ord-39fe4c2e1195477eb249df5a4f124b5a

Reaktionsgleichung

Cl.O=S(=O)(Cl)c1cccc2cnccc12
isoquinoline-5-sulfonyl chloride hydrochloride
CC(C)(CN)CNC(=O)OC(C)(C)C
Intermediate 56
CC(C)(CN)CNC(=O)OC(C)(C)C
3-(N-tert-butoxycarbonylamino)-2,2-dimethylpropylamine
→
CC(C)(CNC(=O)OC(C)(C)C)CNS(=O)(=O)c1cccc2cnccc12
title compound
Ausbeute 97.8%
CC(C)(CNC(=O)OC(C)(C)C)CNS(=O)(=O)c1cccc2cnccc12
N-(tert-butoxycarbonyl)-N′-[(5-isoquinolyl)sulfonyl]-2,2-dimethyl-1,3-propylenediamine
Ausbeute 97.8%

Edukte

Cl.O=S(=O)(Cl)c1cccc2cnccc12
isoquinoline-5-sulfonyl chloride hydrochloride
CC(C)(CN)CNC(=O)OC(C)(C)C
Intermediate 56
CC(C)(CN)CNC(=O)OC(C)(C)C
3-(N-tert-butoxycarbonylamino)-2,2-dimethylpropylamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

According to Reference Example 5, Step B, a reaction was performed by using isoquinoline-5-sulfonyl chloride hydrochloride (7.8 g) and Intermediate 56 (5.97 g) to obtain the title compound (11.36 g).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07094789B2uspto-grants-2006_08