Reaktion #1069215

Reaktionsgleichung

resultant compound

Ethyl 3-Formylindole-2-carboxylate

resultant compound

(Cyclohexyl)methyltriphenylphosphonium Bromide

benzyltriphenylphosphonium bromide

→

desired compound

Ausbeute 73.0%

Ethyl 3-(2-Phenylethenyl)indole-2-carboxylate

Ausbeute 73.0%

Reaktionsbedingungen

Vorschrift

Using the procedure of Example 121 but replacing the resultant compound of Example 98 with the resultant compound of Example 97 and replacing the resultant compound of Example 120 with benzyltriphenylphosphonium bromide gave the desired compound in 73% yield after silica gel chromatography using 4:1 hexane/ethyl acetate. 1H NMR (CDCl3) δ 1.49 (t,J=7 Hz,3H), 4.48 (q,J=7 Hz,2H), 7.2-7.3 (m,2H), 7.35-7.45 (m,5H), 7.60 (br d,J=8 Hz,1H), 8.07 (d,J=16 Hz,1H), 8.16 (d,J=8 Hz,1H), 8.88 (br,1H). Mass spectrum: (M+H)+ =292.

Quelle