Reaktion #1068825

Reaktionsgleichung

6-bromohexanenitrile

4-(2-oxazolyl)phenol monohydrochloride

potassium carbonate

N,N-dimethylformamide

→

6-[4-(4,5-dihydro-2-oxazolyl)phenoxy]hexanenitrile

Ausbeute 20.6%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Extraktionthe product was extracted with methylbenzene
3. 3
   WaschenThe extract was washed with water
4. 4
   Sonstigedried
5. 5
   Filtrationfiltered
6. 6
   Sonstigeevaporated
7. 7
   SonstigeThe residue was crystallized from 2,2'-oxybispropane
8. 8
   FiltrationThe product was filtered off
9. 9
   Sonstigedried

Vorschrift

A mixture of 6-bromohexanenitrile, 12 parts of 4-(2-oxazolyl)phenol monohydrochloride, 16.6 parts of potassium carbonate and 282 parts of N,N-dimethylformamide was stirred overnight at 60° C. After cooling, the reaction mixture was poured into water and the product was extracted with methylbenzene. The extract was washed with water, dried, filtered and evaporated. The residue was crystallized from 2,2'-oxybispropane. The product was filtered off and dried, yielding 3.2 parts (20.6%) of 6-[4-(4,5-dihydro-2-oxazolyl)phenoxy]hexanenitrile (int. 107).

Quelle