Reaktion #10684

ord-aa44ef0c05ad4a6ba243340aa196d0e5

Reaktionsgleichung

BrCCOC1CCCCO1
2-(2-bromoethoxy)tetrahydro-2H-pyran
Cc1cncc2cccc(N[C@H]3CC[C@@H](N)CC3)c12.Cl
compound
Cc1cncc2cccc(N[C@H]3CC[C@@H](N)CC3)c12.Cl
cis-N-(4-methyl-5-isoquinolyl)-1,4-cyclohexanediamine hydrochloride
→
Cc1cncc2cccc(N[C@H]3CC[C@@H](NCCO)CC3)c12.Cl
title compound
Cc1cncc2cccc(N[C@H]3CC[C@@H](NCCO)CC3)c12.Cl
Cis-N-(4-methyl-5-isoquinolyl)-N′-(2-hydroxyethyl)-1,4-cyclohexanediamine hydrochloride

Edukte

BrCCOC1CCCCO1
2-(2-bromoethoxy)tetrahydro-2H-pyran
Cc1cncc2cccc(N[C@H]3CC[C@@H](N)CC3)c12.Cl
compound
Cc1cncc2cccc(N[C@H]3CC[C@@H](N)CC3)c12.Cl
cis-N-(4-methyl-5-isoquinolyl)-1,4-cyclohexanediamine hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigea deprotection reaction

Vorschrift

According to the method of Example 144, an alkylation reaction with 2-(2-bromoethoxy)tetrahydro-2H-pyran and a deprotection reaction were performed by using the compound of Example 120 to obtain the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07094789B2uspto-grants-2006_08