Reaktion #1066281

ord-cbef4ad6e8804bacacb7dcba39d053ae

Reaktionsgleichung

CCCCn1c(=O)c2[nH]c(Br)nc2n(CCCC)c1=O
8-bromo-1,3-di-n-butyl-xanthine
NCc1ccccc1
benzylamine
O=c1[nH]c(=O)c2[nH]cnc2[nH]1
xanthine
→
CCCCn1c(=O)c2[nH]c(NCc3ccccc3)nc2n(CCCC)c1=O
8-benzylamino-1,3-di-n-butyl-xanthine

Edukte

CCCCn1c(=O)c2[nH]c(Br)nc2n(CCCC)c1=O
8-bromo-1,3-di-n-butyl-xanthine
NCc1ccccc1
benzylamine
O=c1[nH]c(=O)c2[nH]cnc2[nH]1
xanthine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    TemperaturHeat together
  2. 2
    TemperaturCool
  3. 3
    SonstigeTriturate with ethanol and water

Vorschrift

Heat together a mixture of one equivalent of 8-bromo-1,3-di-n-butyl-xanthine with three to four equivalents of benzylamine at 160°-180° C. until thin layer chromatography analysis shows that no starting xanthine remains. Cool. Triturate with ethanol and water to yield 8-benzylamino-1,3-di-n-butyl-xanthine.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04666914uspto-grants-1987_05