Reaktion #1066100

Reaktionsgleichung

4,5-dichloro-2-nitro-N-β-aminoethylaniline

2-methoxyethylamine

→

2-chloro-5-β-aminoethylamino-4-nitro-N-β-methoxyethylaniline hydrochloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Sonstigedilution with 200 ml of iced water, the precipitate is recrystallized from isopropanol
3. 3
   workup.DISSOLUTIONAfter being dissolved in a hot mixture of water and alcohol to which hydrochloric acid
4. 4
   workup.ADDITIONhas been added
5. 5
   Sonstigethe expected product precipitates as a hydrochloride
6. 6
   Sonstigedecomposes at 260°-265° C.

Vorschrift

0.1 mole (28.6 g) of 4,5-dichloro-2-nitro-N-β-aminoethylaniline prepared in the 1st stage is heated for 4 h 30 min in 60 ml of 2-methoxyethylamine on a steam bath. After cooling and dilution with 200 ml of iced water, the precipitate is recrystallized from isopropanol. After being dissolved in a hot mixture of water and alcohol to which hydrochloric acid has been added, the expected product precipitates as a hydrochloride. It decomposes at 260°-265° C.

Quelle