Reaktion #10658

Reaktionsgleichung

Intermediate 97

N-(tert-butoxycarbonyl)-N′-(4-methoxy-5-isoquinolyl)-1,4-cyclohexanediamine

hydrogen chloride methanol

→

title compound

N-(4-methoxy-5-isoquinolyl)-1,4-cyclohexanediamine hydrochloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstige(50° C., 2 hours)
2. 2
   Sonstigethe solvent was evaporated under reduced pressure
3. 3
   workup.ADDITIONThe residue was added with methanol (2 ml) and diethyl ether (6 ml)
4. 4
   SonstigeThe deposited precipitates
5. 5
   Filtrationwere collected by filtration
6. 6
   Waschenwashed with diethyl ether

Vorschrift

According to the method of Example 1, Step C, deprotection was performed (50° C., 2 hours) by using Intermediate 97 (372 mg) and 10% hydrogen chloride/methanol solution (10 ml). The reaction mixture was cooled to room temperature, and then the solvent was evaporated under reduced pressure. The residue was added with methanol (2 ml) and diethyl ether (6 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (348 mg) as light yellow powdery solid.

Quelle