Reaktion #10655

Reaktionsgleichung

Intermediate 95

trans-N-(tert-butoxycarbonyl)-N′-(4-methyl-5-isoquinolyl)-1,4-cyclohexanediamine

hydrogen chloride methanol

→

title compound

trans-N-(4-methyl-5-isoquinolyl)-1,4-cyclohexanediamine hydrochloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstige(room temperature, 2 hours)
2. 2
   SonstigeThe solvent was evaporated under reduced pressure
3. 3
   workup.ADDITIONthe residue was added with methanol (2 ml) and diethyl ether (6 ml)
4. 4
   SonstigeThe deposited precipitates
5. 5
   Filtrationwere collected by filtration
6. 6
   Waschenwashed with diethyl ether

Vorschrift

According to the method of Example 1, Step C, deprotection was performed (room temperature, 2 hours) by using Intermediate 95 (389 mg) and 10% hydrogen chloride/methanol solution (10 ml). The solvent was evaporated under reduced pressure, and the residue was added with methanol (2 ml) and diethyl ether (6 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (355 mg) as light yellow powdery solid.

Quelle