Reaktion #1061498

Reaktionsgleichung

4-phenyl-3-buten-1-yl-bromide

2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine

chloroform toluene

→

2-Amino-6-(4-phenyl-3-buten-1-yl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine

Ausbeute 39.0%

Lösungsmittel

chloroform

Reaktionsbedingungen

Vorschrift

Prepared analogously to Example 8 from 4-phenyl-3-buten-1-yl-bromide [boiling point 93° C./1,5 torr; prepared from 1-cyclopropyl-1-phenyl-carbinol with phosphorous tribromide] with 4 equivalents of 2-amino-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine in pure chloroform during 8 hours at 60° C. Yield: 39% of theory, Melting point: 157°-158° C. (chloroform/toluene)

Quelle