Reaktion #1061459

ord-ac24a9a71b774922bd241117f6766417

Reaktionsgleichung

COC(=O)C(=Cc1cccc([N+](=O)[O-])c1)C(C)=O
methyl 2-(3-nitrobenzylidene)-acetoacetate
COCCOC(=O)/C=C(\N)Cn1ccnc1
2-methoxyethyl 3-amino-4-(imidazol-1-yl)crotonate
→
COCCOC(=O)C1=C(Cn2ccnc2)NC(C)=C(C(=O)OC)C1c1cccc([N+](=O)[O-])c1
title compound
COCCOC(=O)C1=C(Cn2ccnc2)NC(C)=C(C(=O)OC)C1c1cccc([N+](=O)[O-])c1
1,4-Dihydro-2-(imidazol-1-ylmethyl)-6-methyl-4-(3-nitro-phenyl)pyridine-3,5-dicarboxylic acid 3-(2-methoxy)ethyl 5-methyl ester

Edukte

COC(=O)C(=Cc1cccc([N+](=O)[O-])c1)C(C)=O
methyl 2-(3-nitrobenzylidene)-acetoacetate
COCCOC(=O)/C=C(\N)Cn1ccnc1
2-methoxyethyl 3-amino-4-(imidazol-1-yl)crotonate

Reagenzien

Keine

Lösungsmittel

CCO
ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturis heated
  2. 2
    Temperaturat reflux for 5 hours

Vorschrift

A mixture of methyl 2-(3-nitrobenzylidene)-acetoacetate (2.5 g, 0.01 mol), ethanol (20 ml) and 2-methoxyethyl 3-amino-4-(imidazol-1-yl)crotonate (3 g) is heated at reflux for 5 hours to give the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05068337uspto-grants-1991_11