Reaktion #1060533
ord-f5ad0926191d484091dc4ea1e159b25c
Reaktionsgleichung
ethyl 7-bromoheptanoate
tert.-butyl 2-(4-acetoxynonyl)-2-(6-methoxycarbonyl-5-methylhexyl)malonate
di-tert.-butyl (6-methoxycarbonyl-5-methylhexyl)malonate
methyl 8carboxy-12-acetoxy-3-methylheptadecanoate
methyl 8-chlorocarbonyl-12-acetoxy-3-methylheptadecanoate
tert.-butyl 2-(4-acetoxynonyl)-2-(6-methoxycarbonyl-5-methylhexyl)malonate
8carbamoyl-12-acetoxy-3-methylheptadecanoic acid
ethyl 8-carbamoyl-12-(S)-hydroxyheptadecanoic acid
methyl 3-methyl-7-iodoheptanoate
methyl 8-carbamoyl-12-acetoxy-3-methylheptadecanote
ethyl 8-carbamoyl-12-(S)-acetoxyheptadecanoate
→
Edukte
ethyl 7-bromoheptanoate
tert.-butyl 2-(4-acetoxynonyl)-2-(6-methoxycarbonyl-5-methylhexyl)malonate
—
product
di-tert.-butyl (6-methoxycarbonyl-5-methylhexyl)malonate
methyl 8carboxy-12-acetoxy-3-methylheptadecanoate
methyl 8-chlorocarbonyl-12-acetoxy-3-methylheptadecanoate
tert.-butyl 2-(4-acetoxynonyl)-2-(6-methoxycarbonyl-5-methylhexyl)malonate
8carbamoyl-12-acetoxy-3-methylheptadecanoic acid
ethyl 8-carbamoyl-12-(S)-hydroxyheptadecanoic acid
methyl 3-methyl-7-iodoheptanoate
methyl 8-carbamoyl-12-acetoxy-3-methylheptadecanote
ethyl 8-carbamoyl-12-(S)-acetoxyheptadecanoate
Reagenzien
Keine
Reaktionsbedingungen
Detaillierte Bedingungen
See reaction.notes.procedure_details.
Aufarbeitung
- 1SonstigeThe synthesis of this compound
Vorschrift
The synthesis of this compound is carried out as described in Example 1 except that, in Step A, the ethyl 7-bromoheptanoate is replaced by an equimolar amount of methyl 3-methyl-7-iodoheptanoate. The product of Step A is thus: di-tert.-butyl (6-methoxycarbonyl-5-methylhexyl)malonate. Subsequent steps yield: di.-tert.-butyl 2-(4-acetoxynonyl)-2-(6-methoxycarbonyl-5-methylhexyl)malonate (D); methyl 8carboxy-12-acetoxy-3-methylheptadecanoate (V); methyl 8-chlorocarbonyl-12-acetoxy-3-methylheptadecanoate (D); methyl 8-carbamoyl-12-acetoxy-3-methylheptadecanote (E); and 8carbamoyl-12-acetoxy-3-methylheptadecanoic acid (F).