Reaktion #1060469

Reaktionsgleichung

1-hydrazino-2-propanol

1-hydrazino-2-hexanol

1-hydrazino-2-butanol

3-(p-fluorobenzoyl)-propionic acid

3-(3,4-dichlorobenzoyl)-propionic acid

→

3-(3,4-dichlorophenyl)-2-(2-hydroxyhexyl)-4,5-dihydropyridazin

3-(p-fluorophenyl)-2-(2-hydroxyhexyl)-4,5-dihydropyridazin

Reaktionsbedingungen

Vorschrift

When the above procedure is carried out using equivalent amounts of 3-(p-fluorobenzoyl)-propionic acid and 1-hydrazino-2-hexanol,3-(3,4-dichlorobenzoyl)-propionic acid and 1-hydrazino-2-propanol or 3-(3,4-dichlorobenzoyl)-propionic acid and 1-hydrazino-2-hexanol in place of the 3-(p-chlorobenzoyl)-propionic acid and 1-hydrazino-2-butanol used therein, there is obtained 3-(p-fluorophenyl)-2-(2-hydroxyhexyl)-4,5-dihydropyridazin (2H)-3-one (m.p. 75°-77° C) 3-(3,4-dichlorophenyl)-2-(2-hydroxypropyl)-4,5-dihydropyridazin(2H)-3-one, (m.p. 108.5°-100° C) or 3-(3,4-dichlorophenyl)-2-(2-hydroxyhexyl)-4,5-dihydropyridazin (2H)-3-one (m.p. 80°-81° C) respectively.

Quelle