Reaktion #1060301

ord-e906395d1c9744f5b48f62a29e9a6279

Reaktionsgleichung

CC(C)c1nc(O)cc(O)n1
4,6-dihydroxy-2-isopropyl-pyrimidine
O=[N+]([O-])O
nitric acid
→
CC(C)c1nc(O)c([N+](=O)[O-])c(O)n1
4,6-dihydroxy-2-isopropyl-5-nitro-pyrimidine

Edukte

CC(C)c1nc(O)cc(O)n1
4,6-dihydroxy-2-isopropyl-pyrimidine
O=[N+]([O-])O
nitric acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.ADDITIONSubsequently the nitration mixture is poured on ice water
  2. 2
    Filtrationfiltered
  3. 3
    Waschenwashed with water
  4. 4
    Trocknendried in vacuo over P2O5

Vorschrift

220 g of 4,6-dihydroxy-2-isopropyl-pyrimidine are added at 0° C to 500 ml of 100% nitric acid and the mixture is stirred for 1 hour. Subsequently the nitration mixture is poured on ice water, filtered, washed with water, and dried in vacuo over P2O5, to yield 110 g of 4,6-dihydroxy-2-isopropyl-5-nitro-pyrimidine; m.p. 300° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04055411uspto-grants-1977_10