Reaktion #1059859

Reaktionsgleichung

p-fluoroacetophenone

N-propylpiperazine

potassium carbonate

→

p-(4-Propyl-1-piperazinyl)acetophenone

Lösungsmittel

dimethyl sulfoxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 33.2 g
2. 2
   Temperaturheated at 95° for 4.5 hours
3. 3
   Temperaturcooled
4. 4
   FiltrationThe precipitate of p-(4-propyl-1-piperazinyl)-acetophenone is collected by filtration
5. 5
   Waschenwashed with water
6. 6
   Sonstigedried
7. 7
   Sonstigem.p. 68°-70° after crystallization from hexane

Vorschrift

A mixture of 33.2 g. of p-fluoroacetophenone, 48.3 g. of N-propylpiperazine and 99.5 g. of potassium carbonate in 100 ml. of dimethyl sulfoxide is stirred and heated at 95° for 4.5 hours, then cooled and poured into ice water. The precipitate of p-(4-propyl-1-piperazinyl)-acetophenone is collected by filtration, washed with water and dried; m.p. 68°-70° after crystallization from hexane.

Quelle