Reaktion #10576

Reaktionsgleichung

2-Naphthoyl chloride

ammonium thiocyanate

Butyl 4-aminobenzoate

→

4-[3-(Naphthalene-2-carbonyl)-thioureido]-benzoic Acid Butyl Ester

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGStirring
2. 2
   workup.WAITis continued overnight at room temperature
3. 3
   FiltrationThe solid, which forms is filtered
4. 4
   Waschenwashed with water (2×5 ml)
5. 5
   Sonstigedried

Vorschrift

2-Naphthoyl chloride (190 mg, 1 mmol) is added to a solution of ammonium thiocyanate (200 mg, about 3 mmol) in acetone (5 ml) and stirred at room temperature for 1 hour. Butyl 4-aminobenzoate (180 mg, 0.93 mmol) is added to the reaction mixture. Stirring is continued overnight at room temperature. The solid, which forms is filtered and washed with water (2×5 ml) followed by acetone/hexane (3:1) (2×10 ml) and dried.

Quelle