Reaktion #1057142

Reaktionsgleichung

product

2-Ethylcyclopropane-1,1-dicarboxylic acid di-tert-butyl ester

potassium tert-butoxide

→

titled product

Ausbeute 69.0%

racemic 2-Ethylcyclopropane-1,1-dicarboxylic acid tert-butyl ester

Ausbeute 69.0%

Lösungsmittel

water

ether

H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with ether (3×)
2. 2
   Sonstigewas acidified with a 10% aq. citric acid solution at 0° C.
3. 3
   Extraktionextracted with EtOAc (3×)
4. 4
   WaschenThe combined organic layers were washed with water (2×), brine
5. 5
   Trocknendried (MgSO4)
6. 6
   Einengenconcentrated in vacuo

Vorschrift

The product of Step 1 (18.3 g, 67.8 mmol) was added to a suspension of potassium tert-butoxide (33.55 g, 299.0 mmol) in dry ether (500 mL) at 0° C., followed by H2O (1.35 mL, 75.0 mmol) and was vigorously stirred overnight at rt. The reaction mixture was poured in a mixture of ice and water and washed with ether (3×). The aqueous layer was acidified with a 10% aq. citric acid solution at 0° C. and extracted with EtOAc (3×). The combined organic layers were washed with water (2×), brine, dried (MgSO4) and concentrated in vacuo to afford the titled product as a pale yellow oil (10 g, 46.8 mmol, 69% yield).

Quelle