Reaktion #1052442

Reaktionsgleichung

hexane

8-methyl 4-quinazolinone

POCl3

dimethyl aniline

→

8-methyl 4 chloro quinazoline

Lösungsmittel

toluene

Reaktionsbedingungen

Vorschrift

4 g of 8-methyl 4-quinazolinone, 5 ml POCl3 and 5 ml dimethyl aniline in 40 ml toluene were refluxed 3.5 hours. Workup and trituration with hexane gave 2.6 g of 8-methyl 4 chloro quinazoline, mp-122° C. NMR CDCl3 δ 9.07(1H,S), 8.12(1H,d,J=7.7 Hz), 7.8(1H,d,J=6.0 Hz), 7.60(1H,t), 2.78(3H,S).

Quelle