Reaktion #10490

Reaktionsgleichung

5-Bromo-2-methyl-benzothiazole

NH4Cl

LiTMP

n-BuLi

para-formaldehyde

→

2-(5-Bromo-benzothiazol-2-yl)-ethanol

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGafter stirring for 4 hours at −78° C.
2. 2
   workup.STIRRINGwhile stirring rapidly
3. 3
   Extraktionthe reaction was extracted with CH2Cl2
4. 4
   Sonstigedried
5. 5
   Einengenconcentrated in vacuo
6. 6
   Sonstigeto give crude product, 1.02 g
7. 7
   SonstigeThe crude product was purified by flash chromatography
8. 8
   Wascheneluting with CH2Cl2
9. 9
   Waschenwith 20% MeOH/CH2Cl2 to elute the product

Vorschrift

To a dry 100 mL flask, 2,2,6′,6′-tetra-methyl piperidine (0.56 g, 4 mmol) and 6 mL of THF was added and cooled to −78° C. Then n-BuLi (1.5 mL, 2.5M) was added rapidly, and the mixture of LiTMP was stirred for 3 hr. 5-Bromo-2-methyl-benzothiazole (0.75 g, 3.3 mmol) was added in solid form in to the reaction at −78° C., and after stirring for 4 hours at −78° C., 6 equivalents of para-formaldehyde was added to the reaction while stirring rapidly. The reaction was worked up by addition of sat. NH4Cl solution, and the reaction was extracted with CH2Cl2 dried, and concentrated in vacuo to give crude product, 1.02 g. The crude product was purified by flash chromatography, eluting with CH2Cl2, then with 20% MeOH/CH2Cl2 to elute the product. 1H NMR (400 MHz, CDCl3) d ppm 3.32 (t, J=5.76 Hz, 2 H) 4.11 (q, J=5.95 Hz, 2 H) 7.48 (dd, J=8.51, 1.92 Hz, 1 H) 7.70 (d, J=8.51 Hz, 1 H) 8.11 (d, J=1.92 Hz, 1 H)

Quelle