Reaktion #1045

Reaktionsgleichung

2,3,3-trifluoro-2-propenyl bromide

triethyl phosphite

→

diethyl (1,1,2-trifluro-2-propenyl)phosphonate

Ausbeute 11.0%

diethyl (2,3,3-trifluro-2-propenyl)phosphonate

Ausbeute 14.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturat reflux for overnight
2. 2
   SonstigeThe residue obtained
3. 3
   Sonstigeafter evaporation of the solvent
4. 4
   Sonstigewas chromatographed over silica gel (hexanes/ethyl acetate/ethanol, 80/20/1)

Vorschrift

A solution of 2,3,3-trifluoro-2-propenyl bromide (5.25 g, 30 mmol) and triethyl phosphite (4.15 g, 25 mmol) in acetonltrile (15 mL) was heated at reflux for overnight. The residue obtained after evaporation of the solvent was chromatographed over silica gel (hexanes/ethyl acetate/ethanol, 80/20/1) to give diethyl (1,1,2-trifluro-2-propenyl)phosphonate (0.8 g, 11%) and diethyl (2,3,3-trifluro-2-propenyl)phosphonate (1.0 g, 14%).

Quelle