Reaktion #1044

Reaktionsgleichung

1,2,4-triazole

3,4,4-trifluoro-3-butenoyl chloride

→

desired product

Ausbeute 94.2%

1-(3,4,4-trifluoro-1-oxo-3-butenyl)-1H-1,2,4-triazole

Ausbeute 94.2%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe mixture was stirred for 30 min
2. 2
   Filtrationfiltered
3. 3
   SonstigeThe residue obtained
4. 4
   Sonstigeafter evaporation of the solvent
5. 5
   workup.DISSOLUTIONwas redissolved in dichloromethane (25 mL)
6. 6
   Filtrationfiltered
7. 7
   SonstigeEvaporation of the solvent

Vorschrift

To a solution of 1,2,4-triazole (1.38 g, 20 mmol) in ethyl acetate (100 mL) was added 3,4,4-trifluoro-3-butenoyl chloride (1.59 g, 10 mmol) at r.t. with stirring. The mixture was stirred for 30 min and filtered. The residue obtained after evaporation of the solvent was redissolved in dichloromethane (25 mL) and filtered. Evaporation of the solvent gave 1.8 g (94%) of the desired product as a dear oil.

Quelle