Reaktion #1029

Reaktionsgleichung

2-acetyl-4-(pyrid-2-yl)-pyrimidine

hydroxylamine

sodium acetate

→

2-acetyl-4-(pyrid-2-yl)-pyrimidine oxime

Ausbeute 91.1%

Lösungsmittel

water

ethanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturto reflux for 1.5 hours
3. 3
   Filtrationfiltered
4. 4
   Waschenwashed with hexane

Vorschrift

A solution of 2-acetyl-4-(pyrid-2-yl)-pyrimidine (1.0 g), hydroxylamine (0.39 g) and sodium acetate (0.62 g) in a mixture of ethanol (10 ml) and water (2 ml) was heated to reflux for 1.5 hours. The reaction was then poured into water the precipitate filtered and washed with hexane to give 2-acetyl-4-(pyrid-2-yl)-pyrimidine oxime (0.98 g, 91% yield) as a white crystalline solid m.p. 196°-8° C.; 1H NMR: 2.50(3H,s); 7.42(1H,m); 7.88(1H,m); 8.30(1H,d); 8.59(1H,d); 8.74(1H,d); 8.90(1H,d); 10.85(1H,brs) ppm.

Quelle