Reaktion #10253

Reaktionsgleichung

Isobutylamine

bromoacetic acid

→

N-isobutylglycine

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISSOLUTIONdissolved
2. 2
   Sonstigethe excess amine was removed
3. 3
   workup.ADDITIONMeOH was added to the resulting oil
4. 4
   EinengenThe resulting mixture was concentrated
5. 5
   SonstigeFinally, a white solid was recrystallized from ethanol/ether

Vorschrift

Isobutylamine (50 mL, 0.5 mol) was cooled in an ice bath, and bromoacetic acid (6.1 g, 43.9 mmol) added slowly as a solid, insuring that each piece dissolved. After stirring overnight, the excess amine was removed and MeOH was added to the resulting oil. The resulting mixture was concentrated, and repeated using MeOH/HCl. Finally, a white solid was recrystallized from ethanol/ether to provide N-isobutylglycine.HCl (3.95 g, 53.7%).

Quelle