Reaktion #10215

ord-6961669486c8494bb2c3a3bdd60048e7

Reaktionsgleichung

N=C(N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
famotidine
N=C(N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
famotidine
NC(=O)c1ccncc1
isonicotinic acid amide
CC(O)C(=O)O
lactic acid
→
CC(O)C(=O)O.NC(=O)c1ccncc1
Isonicotinic Acid Amide Lactic Acid

Edukte

N=C(N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
famotidine
N=C(N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
famotidine
NC(=O)c1ccncc1
isonicotinic acid amide
CC(O)C(=O)O
lactic acid

Reagenzien

Keine

Lösungsmittel

O
water
O
water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.DISSOLUTIONto dissolve them
  2. 2
    workup.ADDITIONwas added
  3. 3
    Sonstigea kinematic viscosity at room temperature of 0.95 centistokes was obtained

Vorschrift

To 1 g of famotidine and 5 g of isonicotinic acid amide were added about 80 ml of water for injection and 2.20 ml of a 100 mg/ml aqueous lactic acid solution, followed by stirring to dissolve them. After complete dissolution of famotidine, water for injection was added to make the total volume 100 ml, whereby an injection solution having a pH of 6.2 and a kinematic viscosity at room temperature of 0.95 centistokes was obtained.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07094414B2uspto-grants-2006_08