Reaktion #1018903

ord-cb4320f3a86045e8ba71d0f15a3e8261

Reaktionsgleichung

Cc1ccc2c(-c3ccc(Cl)cc3)c([C@@H](COC(=O)C(C)(C)C)OC(C)(C)C)c(Cl)cc2n1
compound 1J
Cc1ccc2c(-c3ccc(Cl)cc3)c([C@@H](COC(=O)C(C)(C)C)OC(C)(C)C)c(Cl)cc2n1
(S)-2-tert-butoxy-2-(7-chloro-5-(4-chlorophenyl)-2-methylquinolin-6-yl)ethyl pivalate
Cc1cc2ncccc2c(-c2ccc(Cl)cc2)c1[C@H](O)COC(=O)C(C)(C)C
(S)-2-(5-(4-chlorophenyl)-7-methylquinolin-6-yl)-2-hydroxyethyl pivalate
→
Cc1cc2ncccc2c(-c2ccc(Cl)cc2)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C
Compound 3J
Cc1cc2ncccc2c(-c2ccc(Cl)cc2)c1[C@@H](COC(=O)C(C)(C)C)OC(C)(C)C
(S)-2-tert-butoxy-2-(5-(4-chlorophenyl)-7-methylquinolin-6-yl)ethyl pivalate

Edukte

Cc1ccc2c(-c3ccc(Cl)cc3)c([C@@H](COC(=O)C(C)(C)C)OC(C)(C)C)c(Cl)cc2n1
compound 1J
Cc1ccc2c(-c3ccc(Cl)cc3)c([C@@H](COC(=O)C(C)(C)C)OC(C)(C)C)c(Cl)cc2n1
(S)-2-tert-butoxy-2-(7-chloro-5-(4-chlorophenyl)-2-methylquinolin-6-yl)ethyl pivalate
Cc1cc2ncccc2c(-c2ccc(Cl)cc2)c1[C@H](O)COC(=O)C(C)(C)C
(S)-2-(5-(4-chlorophenyl)-7-methylquinolin-6-yl)-2-hydroxyethyl pivalate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Compound 3J was prepared following the procedure used to prepare compound 1J of Example 1, except that (S)-2-(5-(4-chlorophenyl)-7-methylquinolin-6-yl)-2-hydroxyethyl pivalate (3I) was used instead of compound 1I. LCMS-ESI+ (m/z): 454.3, 456.3 (M+H)+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09296758B2uspto-grants-2016_03