Reaktion #1017728

ord-8581177c91e94e34aee52b7313feaf43

Reaktionsgleichung

O
Water
O=[N+]([O-])c1cnc(Cl)cc1Cl
2,4-dichloro-5-nitropyridine
NCc1ccccc1
benzylamine
CCN(C(C)C)C(C)C
DIPEA
→
O=[N+]([O-])c1cnc(Cl)cc1NCc1ccccc1
Benzyl-(2-chloro-5-nitro-pyridin-4-yl)-amine

Edukte

O
Water
O=[N+]([O-])c1cnc(Cl)cc1Cl
2,4-dichloro-5-nitropyridine
NCc1ccccc1
benzylamine
CCN(C(C)C)C(C)C
DIPEA

Reagenzien

Keine

Lösungsmittel

CN1CCCC1=O
NMP

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeprecipitation of the product
  2. 2
    FiltrationProduct is filtered off
  3. 3
    Sonstigedried under vacuum

Vorschrift

To a stirred solution of 2,4-dichloro-5-nitropyridine E-2.1″ (10.000 g; 51.817 mmol) and benzylamine (5.552 g; 51.817 mmol) in NMP is added DIPEA (20.053 g; 155.451 mmol) at 0° C. The mixture is stirred at RT for 1 h. Water is added, precipitation of the product occurs. Product is filtered off and dried under vacuum.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09296748B2uspto-grants-2016_03