Reaktion #1014270

Reaktionsgleichung

Intermediate 5

3,4-bis(Benzyloxy)-6-ethynylpyridazine

3,4-bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazine

Intermediate 6

3,4-bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazine

1-(difluoromethoxy)-4-iodobenzene

3,4-bis(benzyloxy)-6-ethynylpyridazine

3,4-bis(Benzyloxy)-6-ethynylpyridazine

→

3,4-bis(Benzyloxy)-6-{2-[4-(difluoromethoxy)phenyl]-ethynyl}pyridazine

Ausbeute 58.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigePrepared

Vorschrift

Prepared as described for 3,4-bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazine (Intermediate 6) from 3,4-bis(benzyloxy)-6-ethynylpyridazine (Intermediate 5) and 1-(difluoromethoxy)-4-iodobenzene in 58% yield.

Quelle