Reaktion #1012888

Reaktionsgleichung

6-bromo-8-chloro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

intermediate 12

6-bromo-8-chloro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

phenylboronic acid

→

title compound

8-Chloro-10-methyl-6-phenyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

Reaktionsbedingungen

Vorschrift

The title compound, off-white solid (68 mg, 88%), MS (ISP) m/z=311.5 [(M+H)+], mp 230.5° C., was prepared in accordance with the general method of example 1 from 6-bromo-8-chloro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (intermediate 12) (78.4 mg, 0.25 mmol) and commercially available phenylboronic acid (39.6 mg, 0.325 mmol).

Quelle