Reaktion #1012886

Reaktionsgleichung

6-bromo-8-fluoro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

intermediate 14

6-bromo-8-fluoro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

3,4-dichloro-phenylboronic acid

→

title compound

6-(3,4-Dichloro-phenyl)-8-fluoro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

Reaktionsbedingungen

Vorschrift

The title compound, light yellow solid (63 mg, 69%), MS (ISP) m/z=363.5 [(M+H)+], mp 224° C., was prepared in accordance with the general method of example 1 from 6-bromo-8-fluoro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (intermediate 14) (74.3 mg, 0.25 mmol) and commercially available 3,4-dichloro-phenylboronic acid (62.0 mg, 0.325 mmol).

Quelle