Reaktion #1012883

Reaktionsgleichung

6-bromo-8-fluoro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

intermediate 14

6-bromo-8-fluoro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

pyridine-4-ylboronic acid

→

title compound

8-Fluoro-10-methyl-6-pyridin-4-yl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

Reaktionsbedingungen

Vorschrift

The title compound, light yellow solid (46 mg, 62%), MS (ISP) m/z=296.5 [(M+H)+], mp 290° C., was prepared in accordance with the general method of example 1 from 6-bromo-8-fluoro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (intermediate 14) (74.3 mg, 0.25 mmol) and commercially available pyridine-4-ylboronic acid (39.9 mg, 0.325 mmol).

Quelle