Reaktion #1012882

Reaktionsgleichung

6-bromo-8-fluoro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

intermediate 14

6-bromo-8-fluoro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

4-trifluoromethyl-phenylboronic acid

→

title compound

8-Fluoro-10-methyl-6-(4-trifluoromethyl-phenyl)-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

Reaktionsbedingungen

Vorschrift

The title compound, off-white solid (74 mg, 82%), MS (ISP) m/z=363.4 [(M+H)+], mp 269.5° C., was prepared in accordance with the general method of example 1 from 6-bromo-8-fluoro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (intermediate 14) (74.3 mg, 0.25 mmol) and commercially available 4-trifluoromethyl-phenylboronic acid (61.7 mg, 0.325 mmol).

Quelle