Reaktion #1012880

Reaktionsgleichung

6-bromo-8-fluoro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

intermediate 14

6-bromo-8-fluoro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

phenylboronic acid

→

title compound

8-Fluoro-10-methyl-6-phenyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one

Reaktionsbedingungen

Vorschrift

The title compound, off-white solid (66 mg, 90%), MS (ISP) m/z=295.5 [(M+H)+], mp 244° C., was prepared in accordance with the general method of example 1 from 6-bromo-8-fluoro-10-methyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one (intermediate 14) (74.3 mg, 0.25 mmol) and commercially available phenylboronic acid (39.6 mg, 0.325 mmol).

Quelle