Reaktion #1010606

Reaktionsgleichung

(R)-tert-butyl 2-amino-2-phenylacetate hydrochloride

acetaldehyde

→

title compound

Ausbeute 110.6%

(R)-tert-butyl 2-(ethylamino)-2-phenylacetate

Ausbeute 110.6%

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe ice bath was removed
2. 2
   workup.STIRRINGstirred at rt for 45 mins
3. 3
   FiltrationThe mixture was filtered through celite
4. 4
   Waschenwashed with methanol
5. 5
   Einengenthe filtrate was concentrated in vacuo

Vorschrift

To a solution of (R)-tert-butyl 2-amino-2-phenylacetate hydrochloride (0.25 g, 1.026 mmol) in MeOH (10.26 mL) was added 10% Pd/C (0.080 g, 1.026 mmol). The resulting mixture was cooled to 0° C., and acetaldehyde (0.576 mL, 10.26 mmol) was added. The resulting mixture was stirred at 0° C. for 10-15 mins, the ice bath was removed, and the mixture was placed under a hydrogen balloon and stirred at rt for 45 mins. The mixture was filtered through celite, washed with methanol, and the filtrate was concentrated in vacuo to give the title compound (0.267 g).

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