Reaktion #1009422

Reaktionsgleichung

3-(3,5-Dimethyl-1,2-oxazol-4-yl)-3-(4-hydroxyphenyl)propanoic acid

methanesulfonic acid

→

Methyl 3-(3,5-dimethyl-1,2-oxazol-4-yl)-3-(4-hydroxyphenyl)propanoate

Ausbeute 18.7%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeTo a 25 mL RB flask fitted with magnetic stirrer
2. 2
   workup.ADDITIONAfter addition
3. 3
   Sonstigethe solvent was evaporated
4. 4
   workup.ADDITIONwater (20 mL) was added
5. 5
   Extraktionthe organic layer was extracted with ethyl acetate (15 mL×2)
6. 6
   TrocknenThe organic layer was dried over anhydrous Na2SO4
7. 7
   Sonstigethe solvent was removed under reduced pressure
8. 8
   SonstigeThe product was obtained as brown liquid

Vorschrift

To a 25 mL RB flask fitted with magnetic stirrer was charged 20 mL of methanol. To the stirred solvent was added 3-(3,5-Dimethyl-1,2-oxazol-4-yl)-3-(4-hydroxyphenyl)propanoic acid (1.0 g, 6.1 mmol), followed by methanesulfonic acid (1.16 g, 12.0 mmol). After addition, the RM was refluxed at 65° C. for 1 h. After 1 h, the solvent was evaporated, water (20 mL) was added and the organic layer was extracted with ethyl acetate (15 mL×2). The organic layer was dried over anhydrous Na2SO4 and the solvent was removed under reduced pressure. The product was obtained as brown liquid. (0.2 g, yield: 18.72%).

Quelle