Reaktion #1008696

Reaktionsgleichung

tert-butyl (6-hydroxyhexyl)carbamate

methanesulfonyl chloride

→

6-((tert-Butoxycarbonyl)amino)hexyl methanesulfonate

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe compound was purified by silica chromatography

Vorschrift

To a solution of tert-butyl (6-hydroxyhexyl)carbamate (12.18 g, 56.05 mmol) and TEA (8.51 g, 84.08 mmol) in 100 ml of methylene chloride, methanesulfonyl chloride (9.63 g, 84.08 mmol) was slowly added at 0° C. The mixture was stirred at room temperature overnight. The compound was purified by silica chromatography using heptane/ethyl acetate as eluent.

Quelle