Reaktion #1005985

Reaktionsgleichung

2-chloromethylquinoline hydrochloride

potassium carbonate

tert-butyl piperazine-1-carboxylate

→

2-(piperazin-1-ylmethyl)quinoline

Ausbeute 92.0%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeReaction
2. 2
   Filtrationfiltered through celite
3. 3
   EinengenFiltrate was concentrated on Rotavapor under vacuum
4. 4
   Sonstigethe crude residue was purified on SiO2 using Biotage SP1

Vorschrift

To a solution of 2-chloromethylquinoline hydrochloride (5 mmol) in anhydrous acetone (100 mL) was added, anhydrous potassium carbonate (15 mmol) and tert-butyl piperazine-1-carboxylate (7 mmol) and the reaction mixture was stirred under reflux conditions for 12 h. Reaction was cooled to r.t. and filtered through celite. Filtrate was concentrated on Rotavapor under vacuum and the crude residue was purified on SiO2 using Biotage SP1 to give a pure 2-(piperazin-1-ylmethyl)quinoline (6.3, 92%, pale yellow solid).

Quelle