Reaktion #1005984

Reaktionsgleichung

compound 48

N-(4-azidobutyl)-N-methyl-4-phenyl-1H-imidazole-1-carboxamide

triphenylphosphine

Carbondisulfide

→

crude compound

N-(4-isothiocyanatobutyl)-N-methyl-4-phenyl-1H-imidazole-1-carboxamide

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITthe stirring continued at 50° C. for 4 h
2. 2
   SonstigeReaction
3. 3
   Temperaturwas cooled to r.t.
4. 4
   Sonstigesolvent was evaporated on Rotavapor

Vorschrift

To a compound 48 (0.85 mmol) in anhydrous toluene (20 mL) was added triphenylphosphine (1 mmol) and reaction mixture was stirred at 50° C. for 2 h. Carbondisulfide (10 mmol) was added and the stirring continued at 50° C. for 4 h. Reaction was cooled to r.t. and solvent was evaporated on Rotavapor to give a crude compound which on purification by Biotage SP1 gave a pure isothiocyante 49.

Quelle