Reaktion #1005957

Reaktionsgleichung

5-Bromoindan-1-one

Hydroxylammonium chloride

sodium acetate

→

5-bromo-N-hydroxyindan-1-imine

Ausbeute 95.2%

Lösungsmittel

methanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted twice with ethyl acetate
2. 2
   Waschenwashed with water
3. 3
   Trocknendried over anhydrous magnesium sulfate
4. 4
   FiltrationThe desiccant was filtered
5. 5
   Sonstigeseparated
6. 6
   Sonstigethe solvent was evaporated off under reduced pressure

Vorschrift

5-Bromoindan-1-one (5.0 g) was dissolved in methanol. Hydroxylammonium chloride (2.5 g) and sodium acetate (2.9 g) were added to the solution at room temperature, and then stirred overnight. The reaction solution was diluted with water and extracted twice with ethyl acetate. The organic layers were combined, washed with water, and dried over anhydrous magnesium sulfate. The desiccant was filtered and separated, and then the solvent was evaporated off under reduced pressure to obtain 5-bromo-N-hydroxyindan-1-imine (5.1 g).

Quelle