Reaktion #1005944

Reaktionsgleichung

3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidine

4-fluoro-2-trifluoromethylbenzonitrile

potassium carbonate

N,N-dimethylformamide

→

title compound

Ausbeute 42.5%

4-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoromethyl)-benzonitrile

Ausbeute 42.5%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling the mixture to room temperature
2. 2
   Waschenwashed with water three times
3. 3
   TrocknenThe organic layer was dried over anhydrous magnesium sulfate
4. 4
   SonstigeThe solvent was evaporated off under reduced pressure
5. 5
   Sonstigethe residue was then purified by a column chromatography

Vorschrift

3-(3,5-Dichlorophenyl)-3-(trifluoromethyl)pyrrolidine (5.6 g), 4-fluoro-2-trifluoromethylbenzonitrile (4.5 g) and potassium carbonate (5.4 g) were added to N,N-dimethylformamide (50 mL), and the mixture was stirred at 110° C. for 4 hours. After cooling the mixture to room temperature, the solution was diluted with ethyl acetate and washed with water three times. The organic layer was dried over anhydrous magnesium sulfate. The solvent was evaporated off under reduced pressure, and the residue was then purified by a column chromatography to obtain the title compound (3.8 g).

Quelle