Reaktion #1004621

ord-5c83237152344d1baf773d69860c2c0c

Reaktionsgleichung

COc1cnc(N2CCOCC2)c2sc(NC(=O)Oc3ccccc3)nc12
(7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)-carbamic acid phenyl ester
CN[C@H]1CC[C@H](O)CC1
trans-4-Methylamino-cyclohexanol
→
COc1cnc(N2CCOCC2)c2sc(NC(=O)N(C)[C@H]3CC[C@H](O)CC3)nc12
Trans-1-(4-Hydroxy-cyclohexyl)-3-(7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)-1-methyl-urea

Edukte

COc1cnc(N2CCOCC2)c2sc(NC(=O)Oc3ccccc3)nc12
(7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)-carbamic acid phenyl ester
CN[C@H]1CC[C@H](O)CC1
trans-4-Methylamino-cyclohexanol

Reagenzien

Keine

Lösungsmittel

C1CCOC1
tetrahydrofuran
CC(Cl)Cl
dichloroethane

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

From (7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)-carbamic acid phenyl ester with trans-4-Methylamino-cyclohexanol in dichloroethane and tetrahydrofuran. ES-MS m/e (%): 422 (M+H+, 100).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07273865B2uspto-grants-2007_09