Reaktion #1003456

Reaktionsgleichung

hydroxylamine hydrochloride

2,4-dichloro-5-fluoro-3-formylbenzoic acid

→

3Cyano-2,4-dichloro-5-fluorobenzoic acid

Lösungsmittel

formic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigea clear solution was immediately obtained

Vorschrift

162 g of hydroxylamine hydrochloride were introduced into 2000 ml of formic acid (technical-grade, 85% strength). At 95° C., 950 g of 2,4-dichloro-5-fluoro-3-formylbenzoic acid (moistened with sulphuric acid, 42% strength) were introduced. As a result, the mixture foamed briefly and then a clear solution was immediately obtained. The mixture was then stirred for 4 hours at from 100 to 105° C. (reflux).

Quelle