Reaktion #1001833

ord-76ae13ba93db4ce78e8e70f1e9a58fcd

Reaktionsgleichung

CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)[O-].[K+]
penicillin
CC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1
7-ADCA
Cl
HCl
NC(=O)C(N)c1ccccc1
D-phenylglycinamide
→
CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1
Cephalexin

Edukte

CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)[O-].[K+]
penicillin
—
mixture
CC1=C(C(=O)O)N2C(=O)[C@@H](N)[C@H]2SC1
7-ADCA
Cl
HCl
NC(=O)C(N)c1ccccc1
D-phenylglycinamide

Reagenzien

Keine

Lösungsmittel

—
aqueous solution

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeis carried out at 25° C.
  2. 2
    SonstigeDuring the reaction

Vorschrift

The reaction is carried out at 25° C. and pH 7.5 in a fixed bed reactor. 10 ml of an aqueous solution of a mixture 0.2 M 7-ADCA and 0.2 M D-phenylglycinamide are passed through a column with 0.5 ml of the immobilized penicillin amidase. During the reaction, the pH is kept constant by adding HCl in an attached stirred reservoir container. Samples are taken and analyzed by HPLC as shown in example 5 at particular time intervals.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07264943B2uspto-grants-2007_09