Reaktion #10014

Reaktionsgleichung

2,6-dichloro-purine

4-nitro-aniline

→

2-Chloro-6-(4-nitro-phenyl-amino)-purine

Lösungsmittel

DMF n-butanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe crystal mass which precipitates out
2. 2
   Temperaturon cooling
3. 3
   Filtrationis filtered off
4. 4
   Sonstigedried in vacuo

Vorschrift

1.9 g (10 mmol) of 2,6-dichloro-purine are stirred in 40 ml of DMF/n-butanol (1:3) with 4.1 g (30 mmol) of 4-nitro-aniline at 130° C. for 24 h and the crystal mass which precipitates out on cooling is filtered off and dried in vacuo. 2-Chloro-6-(4-nitro-phenyl-amino)-purine is obtained; m.p.>270° C.; FAB-MS: (M+H)+=291; Rf=0.6 (CH2Cl2:methanol=9:1).

Quelle