Reaktion #1000794

Reaktionsgleichung

N-(3-Chloro-2-methylphenyl)-2,2-dimethylpropanamide

bromine

→

title compound

N-(4-Bromo-3-chloro-2-methylphenyl)-2,2-dimethylpropanamide

Lösungsmittel

AcOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe residue resulting from concentration
2. 2
   Sonstigewas purified by flash chromatography (20-60% EtOAc-hexanes gradient)

Vorschrift

N-(3-Chloro-2-methylphenyl)-2,2-dimethylpropanamide (0.5 g, 2.2 mmol) and bromine (1.4 g, 8.8 mmol) were combined in AcOH (25 mL) at rt for 2 h. The residue resulting from concentration was purified by flash chromatography (20-60% EtOAc-hexanes gradient) to afford the title compound: MS (ES) m/z 305 (M+1).

Quelle