Reaktion #10006

Reaktionsgleichung

isopropanol

2,6-dichloro-purine

3-fluoro-aniline

DMF

→

2-Chloro-6-(3-fluoro-phenyl-amino)-purine

Lösungsmittel

n-butanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe cooled reaction mixture
2. 2
   Sonstigethe crystal mass which has precipitated out
3. 3
   Filtrationis filtered off
4. 4
   Sonstigedried

Vorschrift

2 g (10.58 mmol) of 2,6-dichloro-purine and 5.9 g (52.9 mmol) of 3-fluoro-aniline (Fluka, Buchs, Switzerland) are stirred in 60 ml of n-butanol and 3 ml of DMF at 80° C. for 5 h. The cooled reaction mixture is treated with isopropanol and the crystal mass which has precipitated out is filtered off and dried. 2-Chloro-6-(3-fluoro-phenyl-amino)-purine is obtained; m.p.>250° C.; FAB-MS: (M+H)+=264; Rf=0.3 (CH2Cl2:methanol 9:1).

Quelle