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841444

COC(=O)NN=C=C1c2cc(Cl)c(Cl)cc2N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C1Cl
Reaction #56630
4.31
Ausbeute 85.0%DOI: 10.6084/m9.figshare.5104873.v1
CC(=O)NN=C=C1c2cc(Cl)c(Cl)cc2N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C1Cl
Reaction #56631
4.32
Ausbeute 56.0%DOI: 10.6084/m9.figshare.5104873.v1
CN(C)N=C=C1c2cc(Cl)c(Cl)cc2N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C1Cl
Reaction #56634
4.35
Ausbeute 78.0%DOI: 10.6084/m9.figshare.5104873.v1
CCOc1cc(C(F)(F)F)ccc1C1=NC(c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)N1C(=O)Cl
Reaction #59785
4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride
Ausbeute 98.1%DOI: 10.6084/m9.figshare.5104873.v1
CCOc1cc(C(F)(F)F)ccc1C1=NC(c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)N1C(=O)N1CCN(S(=O)(=O)C(C)C)CC1
Reaction #59787
[4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(propane-2-sulfonyl)-piperazin-1-yl]-methanone
DOI: 10.6084/m9.figshare.5104873.v1
CCOc1cc(C(F)(F)F)ccc1C1=NC(c2ccc(Cl)cc2)C(c2ccc(Cl)cc2)N1C(=O)N1CCN(S(=O)(=O)N2CCOCC2)CC1
Reaction #59790
[4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(morpholine-4-sulfonyl)-piperazin-1-yl]-methanone
Ausbeute 64.0%DOI: 10.6084/m9.figshare.5104873.v1
COC(=O)CCNC(=O)N1CCCC2CCCCC21
Reaction #67494
intermediate
Ausbeute 67.1%DOI: 10.6084/m9.figshare.5104873.v1
—
Reaction #69623
resultant compound
DOI: 10.6084/m9.figshare.5104873.v1
CC(C)(C)OC(=O)N1CCN(C(=O)Cl)CC1
Reaction #86782
tert-butyl 4-(chlorocarbonyl)piperazine-1-carboxylate
Ausbeute 100.0%DOI: 10.6084/m9.figshare.5104873.v1
CC(C)(C)OC(=O)N1CCN(C(=O)N2Cc3[nH]nc(C(=O)N4CCC(c5ccc(F)c(F)c5C(F)(F)F)CC4)c3C2)CC1
Reaction #86783
tert-butyl 4-(3-(4-(3,4-difluoro-2-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-5-carbonyl)piperazine-1-carboxylate
Ausbeute 71.2%DOI: 10.6084/m9.figshare.5104873.v1
COC(=O)CCNC(=O)N1CCCC2CCCCC21
Reaction #155511
intermediate
Ausbeute 67.1%DOI: 10.6084/m9.figshare.5104873.v1
COCc1nn2c(CN3CC(CC(F)(F)Cl)CC3=O)c(C(F)(F)F)nc2s1
Reaction #156741
4-(2-chloro-2,2-difluoroethyl)-1-{[2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}pyrrolidin-2-one
Ausbeute 74.0%DOI: 10.6084/m9.figshare.5104873.v1
O=C1CC(CC(F)(F)Cl)CN1Cc1c(C(F)(F)F)nc2sc(CO)nn12
Reaction #156747
4-(2-chloro-2,2-difluoroethyl)-1-{[2-(hydroxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}pyrrolidin-2-one
Ausbeute 36.0%DOI: 10.6084/m9.figshare.5104873.v1
O=C1C[C@H](CC(F)(F)Cl)CN1CCl
Reaction #156748
(4R)-4-(2-chloro-2,2-difluoroethyl)-1-(chloromethyl)pyrrolidin-2-one
DOI: 10.6084/m9.figshare.5104873.v1
CC(C)(C)OC(=O)NCCN(Cc1ccc(Cl)cc1)C(=O)N1CCN(C(=O)OCc2ccccc2)CC1
Reaction #168168
benzyl 4-((2-(tert-butoxycarbonylamino)ethyl)(4-chlorobenzyl)carbamoyl)piperazine-1-carboxylate
Ausbeute 38.0%DOI: 10.6084/m9.figshare.5104873.v1
CCN(CC)CCN(C(=O)N1CCN(C(=O)OC(C)(C)C)CC1)c1ccc(Cl)cc1
Reaction #168181
tert-butyl 4-(N-(4-chlorophenyl)-N-(2-(diethylamino)ethyl)carbamoyl)piperazine-1-carboxylate
Ausbeute 18.2%DOI: 10.6084/m9.figshare.5104873.v1
CCN(CC)CCN(Cc1ccc(Cl)cc1)C(=O)N1CCN(C(=O)OC(C)(C)C)CC1
Reaction #168191
tert-butyl 4-(N-(4-chlorobenzyl)-N-(2-(diethylamino)ethyl)carbamoyl)piperazine-1-carboxylate
Ausbeute 45.0%DOI: 10.6084/m9.figshare.5104873.v1
N#CC1=Nc2nc(C3CCCC3)[nH]c2C2=NC(Cc3ccccc3)CN12
Reaction #174801
DOI: 10.1039/C8SC04228D
CCOc1cc(C(C)(C)O)ccc1C1=NC(C)(c2ccc(Cl)cc2)C(C)(c2ccc(Cl)cc2)N1C(=O)N1CCN(CCCS(C)(=O)=O)CC1
Reaction #175209
DOI: 10.1039/C8SC04228D
CCOc1cc(C(C)(C)O)ccc1C1=NC(C)(c2ccc(Cl)cc2)C(C)(c2ccc(Cl)cc2)N1C(=O)N1CCN(CC(=O)N2CCCC2)CC1
Reaction #175558
DOI: 10.1039/C8SC04228D
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