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707349

Cl
Reaction #204145
DOI: 10.1039/C8SC04228D
Cc1ccc2c(N3CCC(NC(=O)OC(C)(C)C)C3)nc(-c3c(O)cccc3F)nc2c1
Reaction #231533
DOI: 10.1039/C8SC04228D
Cc1ccc2c(N3CCC(NC(=O)OC4CCOC4)C3)nc(-c3c(O)cccc3F)nc2c1
Reaction #231718
DOI: 10.1039/C8SC04228D
CCOC(=O)NC1CCN(c2nc(-c3c(O)cccc3F)nc3cc(C)ccc23)C1
Reaction #251382
DOI: 10.1039/C8SC04228D
Cc1ccc2c(N3CCC(N)C3)nc(-c3c(O)cccc3F)nc2c1
Reaction #296101
DOI: 10.1039/C8SC04228D
Cc1ccc2c(N3CCC(NC(=O)OCC(C)(C)C)C3)nc(-c3c(O)cccc3F)nc2c1
Reaction #752491
DOI: 10.1039/C8SC04228D
COCCOC(=O)NC1CCN(c2nc(-c3c(O)cccc3F)nc3cc(C)ccc23)C1
Reaction #896560
DOI: 10.1039/C8SC04228D
Cl
Reaction #1232826
DOI: 10.1039/C8SC04228D
Cc1ccc2c(N3CCC(N)C3)nc(-c3c(O)cccc3F)nc2c1
Reaction #1294610
DOI: 10.1039/C8SC04228D
Cc1ccc2c(N3CC[C@@H](N)C3)nc(-c3c(O)cccc3F)nc2c1
Reaction #1780182
(R)-2-(4-(3-aminopyrrolidin-1-yl)-7-methylquinazolin-2-yl)-3-fluorophenol
Ausbeute 93.2%DOI: 10.6084/m9.figshare.5104873.v1
COCCOC(=O)N[C@@H]1CCN(c2nc(-c3c(O)cccc3F)nc3cc(C)ccc23)C1
Reaction #1780183
(R)-2-methoxyethyl 1-(2-(2-fluoro-6-hydroxyphenyl)-7-methylquinazolin-4-yl)pyrrolidin-3-ylcarbamate
Ausbeute 50.0%DOI: 10.6084/m9.figshare.5104873.v1
COCCOC(=O)N[C@@H]1CCN(c2nc(-c3c(O)cccc3F)nc3cc(C)ccc23)C1.Cl
Reaction #1780184
(R)-2-methoxyethyl 1-(2-(2-fluoro-6-hydroxyphenyl)-7-methylquinazolin-4-yl)pyrrolidin-3-ylcarbamate hydrochloride
DOI: 10.6084/m9.figshare.5104873.v1
CCOC(=O)N[C@@H]1CCN(c2nc(-c3c(O)cccc3F)nc3cc(C)ccc23)C1
Reaction #1780209
(R)-ethyl 1-(2-(2-fluoro-6-hydroxyphenyl)-7-methylquinazolin-4-yl)pyrrolidin-3-ylcarbamate
Ausbeute 93.2%DOI: 10.6084/m9.figshare.5104873.v1
CCOC(=O)N[C@@H]1CCN(c2nc(-c3c(O)cccc3F)nc3cc(C)ccc23)C1.Cl
Reaction #1780210
(R)-ethyl 1-(2-(2-fluoro-6-hydroxyphenyl)-7-methylquinazolin-4-yl)pyrrolidin-3-ylcarbamate hydrochloride
Ausbeute 100.0%DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccc2c(N3CC[C@@H](NC(=O)OCC(C)(C)C)C3)nc(-c3c(O)cccc3F)nc2c1
Reaction #1780211
(R)-neopentyl 1-(2-(2-fluoro-6-hydroxyphenyl)-7-methylquinazolin-4-yl)pyrrolidin-3-ylcarbamate
Ausbeute 95.1%DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccc2c(N3CC[C@@H](NC(=O)OCC(C)(C)C)C3)nc(-c3c(O)cccc3F)nc2c1.Cl
Reaction #1780212
(R)-neopentyl 1-(2-(2-fluoro-6-hydroxyphenyl)-7-methylquinazolin-4-yl)pyrrolidin-3-ylcarbamate hydrochloride
Ausbeute 94.0%DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccc2c(N3CC[C@@H](NC(=O)OC(C)(C)C)C3)nc(-c3c(O)cccc3F)nc2c1
Reaction #2149519
tert-butyl(R)-1-(2-(2-fluoro-6-hydroxyphenyl)-7-methylquinazolin-4-yl)pyrrolidin-3-ylcarbamate
DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccc2c(N3CC[C@@H](N)C3)nc(-c3c(O)cccc3F)nc2c1
Reaction #2149520
2-(4-((R)-3-aminopyrrolidin-1-yl)-7-methylquinazolin-2-yl)-3-fluorophenol
DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccc2c(N3CC[C@@H](NC(=O)O[C@H]4CCOC4)C3)nc(-c3c(O)cccc3F)nc2c1
Reaction #2149521
(S)-tetrahydrofuran-3-yl(R)-1-(2-(2-fluoro-6-hydroxyphenyl)-7-methylquinazolin-4-yl)pyrrolidin-3-ylcarbamate
Ausbeute 88.4%DOI: 10.6084/m9.figshare.5104873.v1
Cc1ccc2c(N3CC[C@@H](NC(=O)O[C@H]4CCOC4)C3)nc(-c3c(O)cccc3F)nc2c1.Cl
Reaction #2149522
(S)-tetrahydrofuran-3-yl(R)-1-(2-(2-fluoro-6-hydroxyphenyl)-7-methylquinazolin-4-yl)pyrrolidin-3-ylcarbamate hydrochloride
Ausbeute 76.0%DOI: 10.6084/m9.figshare.5104873.v1
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