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655977

Reaction #46071

ethyl 1(R)-amino-2(S)-vinylcyclopropane carboxylate hydrochloride

DOI: 10.6084/m9.figshare.5104873.v1

C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)OC(C)(C)C)C(=O)OCC

Reaction #46072

ethyl 1(R)-[1-tert-butoxycarbonyl-4(R)-hydroxypyrrolidine-2(S)-carboxamido]-2(S)-vinylcyclopropanecarboxylate

Ausbeute 94.0%DOI: 10.6084/m9.figshare.5104873.v1

C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](O)CN1)C(=O)OCC.Cl

Reaction #46073

ethyl 1(R)-[4(R)-hydroxypyrrolidine-2(S)-carboxamido]-2(S)-vinylcyclopropanecarboxylate hydrochloride

Ausbeute 97.0%DOI: 10.6084/m9.figshare.5104873.v1

C=C(C)[C@@H]1CC[C@]2(NC(=O)NC3(C(=O)O)CC3)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC=C(c6ccc(C(=O)O)cc6)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12

Reaction #172738

title compound

Ausbeute 25.0%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #175848

DOI: 10.1039/C8SC04228D

C=CCOC(=O)C1(NC(=O)c2cnc3n2C(C)(Cc2ccc(-n4cncn4)cc2)C(=O)N3c2cc(Cl)cc(Cl)c2)CC1

Reaction #208015

DOI: 10.1039/C8SC04228D

CC(C)NCC1(c2ccccc2)CC1(NS(=O)(=O)c1ccc(-c2ccc(Cl)cc2)s1)C(=O)OC(C)(C)C

Reaction #246405

DOI: 10.1039/C8SC04228D

C=CC1CC1(NC(=O)C1CC(Oc2cc(-c3nc(C(C)C)cs3)nc3c(Cl)c(OC)ccc23)CN1)C(=O)OCC

Reaction #262438

DOI: 10.1039/C8SC04228D

—

Reaction #307149

foam

Ausbeute 98.0%DOI: 10.6084/m9.figshare.5104873.v1

$CCOC(=O)[C@@]12C[C@@H]1/C=C\CCCCC[C@H](NC(=O)OC(C)(C)C)C(=O)N1C[C@H](Oc3nc4ccccc4nc3-c3ccccc3)C[C@H]1C(=O)N2$

Reaction #325248

title compound

Ausbeute 92.7%DOI: 10.6084/m9.figshare.5104873.v1

$CCNCC.Cc1ncc(C(=O)N[C@H]2CCCCC/C=C\[C@@H]3C[C@@]3(C(=O)O)NC(=O)[C@@H]3C[C@@H](Oc4nc5ccccc5nc4-c4nc5ccccc5s4)CN3C2=O)cn1$

Reaction #325260

(2R,6S,13aS,14aR,16aS,Z)-6-(2-methylpyrimidine-5-carboxamido)-5,16-dioxo-2-(3-(benzo[d]thiazol-2-yl)quinoxalin-2-yloxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxylate diethylamine

DOI: 10.6084/m9.figshare.5104873.v1

$CCNCC.Cc1cnc(C(=O)N[C@H]2CCCCC/C=C\[C@@H]3C[C@@]3(C(=O)O)NC(=O)[C@@H]3C[C@@H](Oc4nc5ccccc5c5ccccc45)CN3C2=O)cn1$

Reaction #325263

(2R,6S,13aS,14aR,16aS,Z)-6-(5-Methylpyrazine-2-carboxamido)-5,16-dioxo-2-(phenanthridin-6-yloxy)-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecine-14a-carboxylate diethylamine

DOI: 10.6084/m9.figshare.5104873.v1

Reaction #333888

ethyl 1-aminocyclopropanecarboxylate hydrochloride

Ausbeute 100.0%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #333889

ethyl 1-(benzyloxycarbonylamino)cyclopropanecarboxylate

Ausbeute 91.0%DOI: 10.6084/m9.figshare.5104873.v1

Reaction #434106

(1R,2S)-1-amino-2-vinylcyclopropane carboxylic acid ethyl ester hydrochloride

DOI: 10.6084/m9.figshare.5104873.v1

C=CC1CC1(NC(=O)C1CC(Oc2nccc3ccccc23)CN1)C(=O)OCC.Cl.Cl

Reaction #434107

1-{[4-(isoquinolin-1-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester, bis hydrochloride

Ausbeute 100.0%DOI: 10.6084/m9.figshare.5104873.v1

C=CCCCCCC(NC(=O)OC(C)(C)C)C(=O)N1CC(Oc2nccc3ccccc23)CC1C(=O)NC1(C(=O)OCC)CC1C=C

Reaction #434108

1-{[1-(2-tert-butoxycarbonylamino-non-8-enoyl)-4-(isoquinolin-1-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester

Ausbeute 79.6%DOI: 10.6084/m9.figshare.5104873.v1

C=CCOCCCC(NC(=O)OC(C)(C)C)C(=O)N1CC(Oc2nccc3cc(OC)ccc23)CC1C(=O)NC1(C(=O)OCC)CC1C=C

Reaction #434135

1-{[1-(5-Allyloxy-2-tert-butoxycarbonylamino-pentanoyl)-4-(6-methoxy-isoquinolin-1-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester

Ausbeute 79.0%DOI: 10.6084/m9.figshare.5104873.v1

C=CCCCN(C[C@H](C(=O)OC(C)(C)C)C(=O)N1C[C@H](Oc2nccc3ccccc23)C[C@H]1C(=O)N[C@]1(C(=O)OCC)C[C@H]1C=C)S(=O)(=O)c1ccccc1[N+](=O)[O-]

Reaction #434146

(1R,2S)-ethyl 1-((3R,5S)-1-((S)-2-(tert-butoxycarbonyl)-3-(2-nitro-N-(pent-4-enyl)phenylsulfonamido)propanoyl)-3-(isoquinolin-1-yloxy)pyrrolidine-5-carboxamido)-2-vinylcyclopropanecarboxylate

Ausbeute 71.1%DOI: 10.6084/m9.figshare.5104873.v1

$C=CCC(C)(C)COC(=O)N[C@H]1CCCCC/C=C\[C@@H]2C[C@@]2(C(=O)OCC)NC(=O)[C@@H]2C[C@@H](Oc3nccc4cc(OC)c(C=C)cc34)CN2C1=O$

Reaction #476401

title product

Ausbeute 85.9%DOI: 10.6084/m9.figshare.5104873.v1

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