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633079

CCOC(=O)C1CCCC1N(Cc1ccc(F)cc1)C(=O)CC1=NS(=O)(=O)c2ccccc2N1
Reaction #177451
DOI: 10.1039/C8SC04228D
CCOC(=O)C1C2CCC(C2)C1N(Cc1ccc(C)c(F)c1)C(=O)CC1=NS(=O)(=O)c2cc(NS(C)(=O)=O)ccc2N1
Reaction #179874
DOI: 10.1039/C8SC04228D
CCOC(=O)C1C2CCC(C2)C1NCc1ccc(F)c(Cl)c1
Reaction #213510
DOI: 10.1039/C8SC04228D
CCOC(=O)[C@@]1(F)[C@@H]2C[C@@H](NCc3ccc(Cl)c(Cl)c3)[C@@](NC(=O)OC(C)(C)C)(C(=O)OCC)[C@@H]21
Reaction #217691
(1R,2R,3R,5R,6R)-2-t-butoxycarbonylamino-3-(3,4-dichlorobenzylamino)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester
Ausbeute 39.3%DOI: 10.6084/m9.figshare.5104873.v1
CCOC(=O)[C@@]1(N)[C@H]2[C@@H](C[C@H]1NCc1ccc(Cl)c(Cl)c1)[C@]2(F)C(=O)OCC
Reaction #217692
(1R,2R,3R,5R,6R)-2-amino-3-(3,4-dichlorobenzylamino)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester
Ausbeute 92.3%DOI: 10.6084/m9.figshare.5104873.v1
CCOC(=O)[C@@]1(F)[C@@H]2C[C@@H](NC(=O)c3ccc(Cl)c(Cl)c3)[C@@](NC(=O)OC(C)(C)C)(C(=O)OCC)[C@@H]21
Reaction #217693
(1R,2R,3R,5R,6R)-2-t-butoxycarbonylamino-3-(3,4-dichlorobenzoylamino)-6-fluoro-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid diethyl ester
Ausbeute 84.5%DOI: 10.6084/m9.figshare.5104873.v1
CCOC(=O)C1C2CCC(C2)C1NCc1ccc(F)cc1
Reaction #375102
DOI: 10.1039/C8SC04228D
CCOC(=O)C1C2CCC(C2)C1N(Cc1ccc(F)cc1)C(=O)CC1=NS(=O)(=O)c2ccccc2N1
Reaction #398390
DOI: 10.1039/C8SC04228D
CCOC(=O)C1(F)C2CC(NC(=O)c3ccc(Cl)c(Cl)c3)C(NC(=O)OC(C)(C)C)(C(=O)OCC)C21
Reaction #400455
DOI: 10.1039/C8SC04228D
CCOC(=O)[C@@H]1[C@H]2CC[C@H](C2)[C@@H]1NCc1ccc(F)cc1
Reaction #508635
(1S,2R,3S,4R)-3-(4-fluorobenzylamino)-bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester
Ausbeute 95.1%DOI: 10.6084/m9.figshare.5104873.v1
CCOC(=O)[C@@H]1CCC[C@@H]1NCc1ccc(F)cc1
Reaction #508638
cis-2-(4-fluoro-benzylamino)-cyclopentanecarboxylic acid ethyl ester
Ausbeute 77.0%DOI: 10.6084/m9.figshare.5104873.v1
—
Reaction #508640
(1S,2R,3S,4R)-3-(4-fluoro-benzyl)-6-hydroxy-5-(7-iodo-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-3-aza-tricyclo[6.2.1.02,7]undec-5-en-4-one
Ausbeute 48.0%DOI: 10.6084/m9.figshare.5104873.v1
COCOCc1csc2c1S(=O)(=O)N=C(C1=C(O)[C@@H]3[C@H]4CC[C@H](C4)[C@@H]3N(Cc3ccc(F)cc3)C1=O)N2
Reaction #508692
(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-5-(7-methoxymethoxymethyl-1,1-dioxo-1,4-dihydro-1λ6-thieno[2,3-e][1,2,4]thiadiazin-3-yl)-3-aza-tricyclo[6.2.1.02,7]undec-5-en-4-one
Ausbeute 67.0%DOI: 10.6084/m9.figshare.5104873.v1
CCOC(=O)[C@@H]1[C@H]2CC[C@H](C2)[C@@H]1NCc1ccc(F)cc1
Reaction #511380
(1S,2R,3S,4R)-3-(4-fluorobenzylamino)-bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester
Ausbeute 95.1%DOI: 10.6084/m9.figshare.5104873.v1
—
Reaction #511381
crude product
DOI: 10.6084/m9.figshare.5104873.v1
CS(=O)(=O)Nc1ccc2c(c1)S(=O)(=O)N=C(C1=C(O)[C@@H]3[C@H]4CC[C@H](C4)[C@@H]3N(Cc3ccc(F)cc3)C1=O)N2
Reaction #511382
N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide
Ausbeute 68.0%DOI: 10.6084/m9.figshare.5104873.v1
CS(=O)(=O)Nc1ccc2c(c1)S(=O)(=O)N=C(C1=C(O)[C@@H]3[C@H]4CC[C@H](C4)[C@@H]3N(Cc3ccc(F)cc3)C1=O)N2
Reaction #511383
N-{3-[(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-4-oxo-3-aza-tricyclo[6.2.1.02,7]undec-5-en-5-yl]-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide
Ausbeute 78.0%DOI: 10.6084/m9.figshare.5104873.v1
O=C1C(C2=NS(=O)(=O)c3cc(I)ccc3N2)=C(O)[C@@H]2[C@H]3CC[C@H](C3)[C@@H]2N1Cc1ccc(F)cc1
Reaction #511396
(1R,2S,7R,8S)-3-(4-fluoro-benzyl)-6-hydroxy-5-(7-iodo-1,1-dioxo-1,4-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-3-aza-tricyclo[6.2.1.02,7]undec-5-en-4-one
Ausbeute 49.3%DOI: 10.6084/m9.figshare.5104873.v1
O=C1C(C2=Nc3ccccc3S(=O)(=O)N2)=C(O)[C@@H]2[C@H]3CC[C@H](C3)[C@@H]2N1Cc1ccc(F)cc1
Reaction #511407
(1R,2S,7R,8S)-5-(1,1-dioxo-1,2-dihydro-1λ6-benzo[1,2,4]thiadiazin-3-yl)-3-(4-fluoro-benzyl)-6-hydroxy-3-aza-tricyclo[6.2.1.02,7]undec-5-en-4-one
Ausbeute 62.1%DOI: 10.6084/m9.figshare.5104873.v1
CCOC(=O)[C@@H]1[C@H]2CC[C@H](C2)[C@@H]1NCc1ccccc1
Reaction #511438
(1S,2R,3S,4R)-3-benzylamino-bicyclo[2.2.1]heptane-2-carboxylic acid ethyl ester
Ausbeute 72.0%DOI: 10.6084/m9.figshare.5104873.v1
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