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CCN1CCCOc2cc(Nc3ncc(Cl)c(NC4CCCCC4NS(C)(=O)=O)n3)c(F)cc21
Reaction #175234
DOI: 10.1039/C8SC04228D
C#CCNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(c2)OCCCN3CC)ncc1Cl
Reaction #226739
DOI: 10.1039/C8SC04228D
CCN1CCCOc2cc(N)ccc21
Reaction #233120
DOI: 10.1039/C8SC04228D
CCN1CCCOc2cc(N)c(F)cc21
Reaction #286559
DOI: 10.1039/C8SC04228D
CCN1CCCOc2ccc(N)cc21
Reaction #401159
DOI: 10.1039/C8SC04228D
CCN1CCCOc2ccc(Nc3ncc(Cl)c(Nc4ccsc4C(=O)NC)n3)cc21
Reaction #902472
DOI: 10.1039/C8SC04228D
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Reaction #1128612
foam
Ausbeute 20.0%DOI: 10.6084/m9.figshare.5104873.v1
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Reaction #1128615
solid
Ausbeute 60.0%DOI: 10.6084/m9.figshare.5104873.v1
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Reaction #1128635
solid
Ausbeute 30.0%DOI: 10.6084/m9.figshare.5104873.v1
CCN1CCCOc2cc(N)c(F)cc21
Reaction #1128829
9-Ethyl-2-fluoro-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-3-ylamine
DOI: 10.6084/m9.figshare.5104873.v1
CCN1CCCOc2cc(Nc3ncc(Cl)c(N[C@@H]4CCCC[C@H]4NS(C)(=O)=O)n3)c(F)cc21
Reaction #1128830
N-{(1R,2R)-2-[5-Chloro-2-(9-ethyl-2-fluoro-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-3-ylamino)-pyrimidin-4-ylamino]-cyclohexyl}-methanesulfonamide
DOI: 10.6084/m9.figshare.5104873.v1
CCN1CCCOc2cc(Nc3ncc(Cl)c(Nc4ccc(N5CCOCC5)cc4OC)n3)c(F)cc21
Reaction #1128831
5-Chloro-N*2*-(9-ethyl-2-fluoro-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-3-yl)-N*4*-(2-methoxy-4-morpholin-4-yl-phenyl)-pyrimidine-2,4-diamine
DOI: 10.6084/m9.figshare.5104873.v1
CCN1CCCOc2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)c(F)cc21
Reaction #1128838
2-[5-Chloro-2-(9-ethyl-2-fluoro-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-3-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide
Ausbeute 7.1%DOI: 10.6084/m9.figshare.5104873.v1
CCN1CCCOc2cc(N)ccc21
Reaction #1128842
9-Ethyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-3-ylamine
DOI: 10.6084/m9.figshare.5104873.v1
CCN1CCCOc2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc21
Reaction #1128843
2-[5-Chloro-2-(9-ethyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-3-ylamino)-pyrimidin-4-ylamino]-3-fluoro-N-methyl-benzamide
Ausbeute 43.0%DOI: 10.6084/m9.figshare.5104873.v1
CCN1CCCOc2cc(Nc3ncc(Cl)c(N[C@@H]4CCCC[C@H]4NS(C)(=O)=O)n3)ccc21
Reaction #1128844
N-{(1R,2R)-2-[5-Chloro-2-(9-ethyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-3-ylamino)-pyrimidin-4-ylamino]-cyclohexyl}-methanesulfonamide
DOI: 10.6084/m9.figshare.5104873.v1
CCN1CCCOc2cc(Nc3ncc(Cl)c(Nc4ccc(N5CCOCC5)cc4OC)n3)ccc21
Reaction #1128845
5-Chloro-N*2*-(9-ethyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-3-yl)-N*4*-(2-methoxy-4-morpholin-4-yl-phenyl)-pyrimidine-2,4-diamine
Ausbeute 102.3%DOI: 10.6084/m9.figshare.5104873.v1
CCN1CCCOc2ccc(N)cc21
Reaction #1128850
9-Ethyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-2-ylamine
DOI: 10.6084/m9.figshare.5104873.v1
CCN1CCCOc2ccc(Nc3ncc(Cl)c(Nc4ccsc4C(=O)NC)n3)cc21
Reaction #1128851
3-[5-Chloro-2-(9-ethyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-2-ylamino)-pyrimidin-4-ylamino]-thiophene-2-carboxylic acid methylamide
Ausbeute 49.0%DOI: 10.6084/m9.figshare.5104873.v1
CCN1CCCOc2cc(Nc3ncc(Cl)c(NC4CCCCC4NS(C)(=O)=O)n3)ccc21
Reaction #1304487
DOI: 10.1039/C8SC04228D
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