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CCCCN

Cc1c(N2CCC(C(C)(C)N)C2)c(F)cn2c(=O)c(C(=O)O)cc(C3CC3)c12.Cl

DOI: 10.6084/m9.figshare.5104873.v1

CC(=O)NC(Cc1ccc(O)cc1)C(=O)NC(Cc1ccc(F)cc1)C(=O)N1CC(Cc2ccc3ccccc3c2)NC(=O)C1Cc1c[nH]cn1

desired product

DOI: 10.6084/m9.figshare.5104873.v1

$COc1ccc(CN2C(=O)CC[C@@H]2/C=C(\c2ccc(C(C)(C)C)cc2)c2ccc(C(C)OC(=S)SC)c(OC)n2)c(OC)c1$

Reaction #157836

O-[1-(6-{(E)-1-(4-tert-butylphenyl)-2-[(2R)-1-(2,4-dimethoxybenzyl)-5-oxopyrrolidin-2-yl]ethenyl}-2-methoxypyridin-3-yl)ethyl] S-methyl carbonodithioate

DOI: 10.6084/m9.figshare.5104873.v1

CCc1ccc(/C(=C/[C@H]2CCC(=O)N2Cc2ccc(OC)cc2OC)c2ccc(C(C)(C)C)cc2)nc1OC

Reaction #157837

(5R)-5-[(E)-2-(4-tert-butylphenyl)-2-(5-ethyl-6-methoxypyridin-2-yl)ethenyl]-1-(2,4-dimethoxybenzyl)pyrrolidin-2-one

Ausbeute 71.6%DOI: 10.6084/m9.figshare.5104873.v1

$COc1ccc(CN2C(=O)CC[C@@H]2/C=C(\c2ccc(C(C)(C)C)cc2)c2ccc(CCCCOS(C)(=O)=O)c(OC)n2)c(OC)c1$

Reaction #157846

4-(6-{(E)-1-(4-tert-butylphenyl)-2-[(2R)-1-(2,4-dimethoxybenzyl)-5-oxopyrrolidin-2-yl]ethenyl}-2-methoxypyridin-3-yl)butyl methanesulfonate

DOI: 10.6084/m9.figshare.5104873.v1

$COc1ccc(CN2C(=O)CC[C@@H]2/C=C(\c2ccc(C(C)(C)C)cc2)c2ccc(CCCCN(C)C)c(OC)n2)c(OC)c1$

Reaction #157847

(5R)-5-[(E)-2-(4-tert-butylphenyl)-2-{5-[4-(dimethylamino)butyl]-6-methoxypyridin-2-yl}ethenyl]-1-(2,4-dimethoxybenzyl)pyrrolidin-2-one

DOI: 10.6084/m9.figshare.5104873.v1

CC(C)N1CCC(Oc2cc3cc(C(=O)N4CCN(C(=O)C5CC5)CC4)[nH]c3cc2Br)CC1

Reaction #188624

DOI: 10.1039/C8SC04228D

CC(=O)N1CCN(C(=O)c2cc3cc(OC4CCN(C(C)C)CC4)ccc3n2C(C)C)CC1

Reaction #190962

DOI: 10.1039/C8SC04228D

CN(CCO)C(=O)CC1CCN(C(=O)C2NC(CC(C)(C)C)C(C#N)(c3ccc(Cl)cc3F)C2c2cccc(Cl)c2F)CC1

Reaction #192114

DOI: 10.1039/C8SC04228D

CCOCCn1c(NC2CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)nc2ccccc21

Reaction #196540

DOI: 10.1039/C8SC04228D

CCN(CC)C(=O)N1CCN(C(=O)c2cc3cc(OC4CCN(C(C)C)CC4)ccc3[nH]2)CC1

Reaction #199979

DOI: 10.1039/C8SC04228D

CCOC(=O)Cn1cccc1C=C1CN(C(c2ccccc2)(c2ccccc2)c2ccccc2)CCC1=O

Reaction #205333

DOI: 10.1039/C8SC04228D

COC(=O)NCC1CCC(C(=O)N2CC(c3ccc(F)cc3)C(N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1

Reaction #205365

DOI: 10.1039/C8SC04228D

CC(C)N1CCC(Oc2ccc3c(c2)cc(C(=O)N2CCS(=O)(=O)CC2)n3C(C)C)CC1

Reaction #207138

DOI: 10.1039/C8SC04228D

Cc1cc(C(O)C(C)N2CCC(O)(c3ccc(F)cc3)CC2)ccc1O[Si](C(C)C)(C(C)C)C(C)C

Reaction #208328

DOI: 10.1039/C8SC04228D

Nc1cc(Cl)c(C(F)(F)F)cc1NC(=O)CCC1CC(=O)C1

Reaction #210048

DOI: 10.1039/C8SC04228D

CN1CC(c2ccc(F)cc2)C2(CCCN(C(=O)C(COCc3ccccc3)NC(=O)C(C)(C)NC(=O)OC(C)(C)C)C2)C1=O

Reaction #213709

DOI: 10.1039/C8SC04228D

COC(=O)NC1CCC(C(=O)N2CC(c3ccc(F)cc3)C(N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1

Reaction #223437

DOI: 10.1039/C8SC04228D

CC(C)(C)CC1CN(C(=O)Nc2ccc(C#N)cc2)C(c2cccc(Cl)c2F)C1(C#N)c1ccc(Cl)cc1F

Reaction #227038

DOI: 10.1039/C8SC04228D

O=C(O)c1cn(C2CC2)c2c(Cl)c(N3CCC(CNCCF)C3)c(F)cc2c1=O

Reaction #228658

DOI: 10.1039/C8SC04228D

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